U.S. Route 11 (US 11) runs southwest to northeast across northcentral Alabama for 250.671 miles (403.416 km).

It enters the state from Mississippi concurrent with US 80 and exits into Georgia east of Sulphur Springs.

US 11 runs through the major cities of Tuscaloosa and Birmingham, as well as the smaller cities and towns of Cuba, York, Livingston, Epes, Boligee, Eutaw, Cottondale, Coaling, Woodstock, Bessemer, Brighton, Midfield, Trussville, Argo, Springville, Ashville, Steele, Attalla, Reece City, and Collinsville.

Aside from portions within major cities and towns, US 11 is largely a rural two-lane road.

Starting at the Mississippi state line, US 11, along with US 80, travel northeast toward Cuba.

After traversing through Epes, US 11 crosses above the Tombigbee River south of Fort Tombecbe, part of the Tennessee–Tombigbee Waterway.

Between the Mississippi state line and Birmingham, US 11 roughly follows a route surveyed by pathfinders in 1912.

[2] In 2024, ALDOT will began work to convert the US 11 (Skyland Boulevard)/SR 69 intersection into a single-point urban interchange (SPUI) in order to improve traffic flow.

The project, which is a joint effort between the Tuscaloosa Road Improvement Commission and ALDOT, is expected to cost $89 million and take about three years to complete.