It runs parallel to Dr. Santos Avenue in the north and is named after the two barangays it links: Alabang, Muntinlupa and Zapote in Bacoor and Las Piñas.

Since 1997, it has also extended further west for several hundred meters, connecting Las Piñas to its present terminus at Coastal Road (R-1) in Bacoor, Cavite.

A spur carrying southbound traffic also branches the highway to the front of Starmall Alabang at Manila South Road.

West of Investment Drive (the northern extension of Daang Hari Road) at Madrigal Business Park, it enters Las Piñas and goes past the commercial and residential areas of the city.

As of July 2016[update], the Las Piñas Traffic Management Office reported that more than 70,000 vehicles were travelling on Alabang–Zapote Road daily, already reaching above its allowable capacity.