It runs north-south from Ocampo Street, which is on the border with Malate, Manila, to Andrews Avenue in Maricaban.

It is interrupted by Epifanio de los Santos Avenue (EDSA) and the MRT Line 3, which divides the road into two sections.

Subsequent development of Manila International Airport led to the closure of a large segment of the old line in Pasay and Parañaque.

The line resumes in La Huerta, where it is still named Tramo Road, running 4.6 kilometers (2.9 mi) to C-5 Extension in Las Piñas and continues as Fruto Santos Avenue.

Streets of the same name, also occupying the former right-of-way of the old railroad line, are found in Bacoor, Tanza, and Naic in Cavite.