8086223921ENSG00000094914ENSMUSG00000036678Q9NRG9P58742NM_001173466NM_015665NM_153416NP_001166937NP_056480NP_700465Aladin, also known as adracalin, is a nuclear envelope protein that in humans is encoded by the AAAS gene.

Aladin is a component of the nuclear pore complex, to which it is attached by nucleoporin NDC1.

[6][7] Mutant aladin causes selective failure of nuclear protein import and hypersensitivity to oxidative stress.

[8] Mutant aladin also causes decreased nuclear import of aprataxin, a repair protein for single-strand breaks, and DNA ligase I, employed in DNA base excision repair.

[8] These decreases in DNA repair proteins may increase the susceptibility of cells to oxidative stress by allowing accumulation of oxidative DNA damages that trigger cell death.