[5] and protein tagging reveals its primarily located on the luminal side of double layer membrane at the pore.

A single polypeptide motif of gp210 is responsible for sorting to nuclear membrane,[6] and indicate the carboxyl tail of the protein is oriented toward the cytoplasmic side of the membrane.

[8] Nuclear lamins begin to reassemble around chromosomes at the end of mitosis.

[11] The replacement of serine at position 1880 with a phosphorylated 'looking' glutamate results in Nup210 complexes that fail to reassemble indicating that dephosphorylation of Nup210 within the final phases of proper assembly is required.

One idea for the loss of tolerance is the increased or abnormal expression of Nup210 in patients with PBC.