Alambique Creek, or Arroyo Alembique, is a 2.7-mile-long (4.3 km)[1] stream located in San Mateo County, California, in the United States.

The name refers to moonshiners Tom Bowen and Nicholas Dawson, English seaman deserters, who built an illegal still on the creek in 1842.

Of note, Lloyd's Pond is likely named for William Lloyd (1823-1895), who operated a blacksmith shop in historic Searsville, and who partnered with other early pioneers Dr. Robert O. Tripp, James "Grizzly" Ryder, and Alvinza Hayward, a bullwhacker from Amador County, to harvest the redwoods.

In 1981, the creek was fish sampled and two stream resident rainbow trout which have been isolated from the Bay by Searsville Dam were collected where the creek crosses La Honda Road.

In May 2002, the culvert beneath Highway 84 was identified as an impassable barrier to upstream migration.