It opened first in 1859 in Shkoder, then the center of Scutari Vilayet of Ottoman Empire.
In 1870, the seminary brought to life its own printing press called "Press of the Immaculate Virgin" (Albanian: Shtypshkroja e Zojes s'Paperlyeme).
[1] The press printed in 1876 its own book, Christian Doctrine (Albanian: Dotrina e kerscten) of Engjell Radoja (1820-1880), which would be followed by many others.
[2] With the rise of Communism in Albania, the Jesuits would be targets of persecution.
[4] With the reestablishment of diplomatic relations between Albania and the Holy See in 1991, the college reopened in October of the same year.