Okwuegbunam attended Sacred Heart-Griffin High School in Springfield, Illinois.
[3] After redshirting his first year at Missouri in 2016, Okwuegbunam played in all 13 games in 2017 and recorded 29 receptions for 415 yards and 11 touchdowns.
[6][7] Following the 2019 season, Okwuegbunam decided to forgo his final year of eligibility and declared for the 2020 NFL draft.
[8] Okwuegbunam was selected by the Denver Broncos in the fourth round with the 118th overall pick in the 2020 NFL draft, reuniting with his former Missouri teammate, Drew Lock.
[15] In 2022, Okwuegbunam played in 8 games for Denver, catching 10 passes for 95 yards and one touchdown.