He played college football for the Oklahoma Sooners and Ohio State Buckeyes and was selected by the San Francisco 49ers in the third round of the 2021 NFL draft.

[2][3] As a true freshman at Oklahoma in 2017, Sermon played in all 14 games and made three starts.

[4] As a sophomore in 2018, he shared time with Kennedy Brooks, rushing for 947 yards on 164 carries and 13 touchdowns.

[6] Sermon transferred to Ohio State University as a graduate student in 2020.

[12] Sermon was selected by the San Francisco 49ers in the third round (88th overall) of the 2021 NFL draft.

[26] On September 19, 2023, Sermon was signed to the practice squad of the Indianapolis Colts.