He played college football for the Alabama Crimson Tide, and was selected by the Colts in first round of the 2016 NFL draft.

[4] After redshirting his initial year in Tuscaloosa, Kelly came off the bench to play in 10 games of the 2012 season at center, backing up All-American senior Barrett Jones.

[5] In his sophomore year, Kelly took over starting duties from Jones, making the calls on an offensive line that ranked 23rd nationally and fourth in the SEC for fewest sacks allowed per game (1.31).

A highly reliable anchor on the offensive line, he missed just seven assignments in 806 snaps on the year for a 99.1 percent success rate and did not allow a quarterback sack.

On August 17, 2017, it was revealed that Kelly would undergo foot surgery for a broken bone he suffered during practice.

[16] On September 4, 2020, the Colts signed Kelly to a four-year, $50 million extension, making him the highest paid center in the NFL.