Despite not having played organized football since he was a freshman in high school, Alie-Cox signed as an undrafted free agent with the Colts in 2017.

Alie-Cox was a four-year standout playing power forward at Virginia Commonwealth University's Men's basketball team.

[2] He also led VCU to its first ever Atlantic 10 Conference championship, earning all tournament team honors.

On April 21, 2017, Alie-Cox signed with the Indianapolis Colts, having not played organized football since his freshman year of high school.

[15] He recorded his first career touchdown catch, a highlight reel one-handed grab, on a 26-yard reception from Andrew Luck in a 42–28 victory over the Oakland Raiders on October 28, 2018.

[19] On September 20, 2020, Alie-Cox had five receptions for 111 receiving yards helping the Colts win 28–11 over the Minnesota Vikings.