After leaving the park, the highway generally travels east, passing by the hamlets of Mountain View and Leavitt, to the Town of Cardston.

[1] After Cardston, the highway generally travels northeast, passing by the Hamlet of Spring Coulee, the Town of Magrath, and the Hamlet of Welling Station.

Shortly after Welling Station, the highway travels north, passing the Hamlet of Welling, before ending at Highway 3 in Lethbridge.

[2][3] Highway 5 is known as Mayor Magrath Drive within Lethbridge city limits.

The following is a list of major intersections along Alberta Highway 5 from southwest to northeast.