It spans approximately 74 kilometres (46 mi) from Alberta's border with Montana to Highway 3 (Crowsnest Highway).

[2][3] Highway 6 is part of the Cowboy Trail between Highway 5 in Waterton Lakes National Park and the Crowsnest Highway, where the Cowboy Trail follows Highway 3 to Highway 22 and continues north.

[4] Montana Highway 17 in Glacier National Park becomes Alberta Highway 6 in Waterton Lakes National Park as it crosses the Canada–United States border at Chief Mountain.

Generally travelling in a north direction from Chief Mountain, the highway provides access to the Hamlet of Waterton Park via Highway 5, and passes through the Hamlet of Twin Butte and the Town of Pincher Creek.

[1][3] The following is a list of major intersections along Alberta Highway 6 from south to north.