She taught at her alma mater's Faculty of Philosophy and Letters between 1968 and 1974, and served as Secretary of Culture by Buenos Aires Province Governor Oscar Bidegain during his brief 1973-74 tenure.

She worked in the Latin American Institute of Transnational Studies (ILET), published numerous articles for IPECAL, and served as adviser to Gabriel García Márquez and Juan Somavía in a discussion regarding New World Information and Communication Order hosted by UNESCO.

[2][4] She became a regular contributor to Página/12, and joined Nobel Peace Prize laureate Adolfo Pérez Esquivel and others in the Forum for Thought and Social Construction.

[5] Argumedo was named in 2005 to the board of directors of the Institute for the Site of Remembrance, which administers the largest former detention center used during the Dirty War as a museum.

[7] Following Solanas' departure from the Socialist Party-led Progressive Front in June 2011, he nominated Argumedo as the Proyecto Sur candidate for president in the 2011 elections.