He lost his left hand in a hunting accident as a boy; despite his disability he still dedicated himself to the art of goldsmithing in the family business.
[citation needed] The younger Castellani was a follower of the Italian nationalist leader Giuseppe Mazzini, and supported the Roman Republic.
[citation needed] In Paris he opened a branch of his father's company on the Champs-Élysées and began the diffusion of Castellani jewels into Europe and then in the United States.
The London location served to introduce Castellani jewelry to a wider audience, particularly among British clients and collectors.
[3][4] Alessandro Castellani played a significant role in organizing exhibitions that showcased the firm's work, notably in Florence (1861) and London (1862)[5], where he presented the "Mundus Muliebris" collection.