At the age of eight, he began playing football with the neighbouring kids and was later enrolled to a youth academy of Esporte Clube Juventude.

Telles began his professional career with Juventude, making his debut on 24 January 2011 against São José-PA.[4] He scored his first goal on 20 August in a 1–1 home draw against Cruzeiro.

mentioning Telles as a good choice to fill the place made by the departure of left-back Filipe Luís at Chelsea.

[citation needed] On 31 August 2015, Galatasaray agreed to let Telles join Italian club Internazionale of Serie A on a one-year loan for a €1.3 million fee, in addition to €250,000 if Inter qualify for the group stage of the 2016–17 UEFA Champions League.

[15] He made his debut for the club on 13 September in the 2015–16 Serie A matchday 3 against city rivals Milan, playing the entirety of the match as Inter won 1–0.

"[18] On 12 August, in a 3–1 away win against Rio Ave, he marked his league debut and first competitive match with a poor performance and subsequent expulsion.

[22][23][24] He made his debut playing as a left wing-back on 20 October in a 2–1 win over Paris Saint-Germain in the UEFA Champions League group stage.

[25] On 29 September 2021, Telles scored his first goal for Manchester United with a left-footed volley from outside the penalty area in a 2–1 home win against Villarreal CF in the 2021–22 UEFA Champions League group stage.

[29] On 25 July, head coach Luís Castro made Telles' debut in a pre-season friendly against Paris Saint-Germain, resulting in a 0-0 tie in Japan.

[33] Although he was born in Brazil, Telles also has an Italian passport,[34] making him in the past eligible to represent Italy national team.