[2] In 2004, he achieved international stardom playing the protagonist Miguel Arango in the Mexican telenovela Rebelde, which spanned the pop musical group RBD (2004–09).

[5] From 2015 to 2018, he sensitively portrayed art lecturer, Hernando Fuentes, secret boyfriend of actor Lito Rodriguez, in the American drama series Sense8 on Netflix.

Herrera portrayed Ignacio de la Torre y Mier in Dance of the 41 (2020) and received acclaim for his performance, winning the Ariel Award for Best Actor.

He changed his mind and decided to enroll at the Centro de Educación Artística run by Latin American media giant Televisa.

In 2002, he was cast in the film Amar te duele, directed by Fernando Sariñana, and from there moved into television, working in the telenovela Clase 406, alongside Dulce María, Anahí, and Christian Chávez, who later became his bandmates in RBD.

They have sold over 15 million albums worldwide, and have toured across Mexico, South America, Serbia, Romania, the United States, and Spain.

Poncho wrote the song "Si No Estas Aqui" on the fifth studio album by the Mexican band RBD, Empezar Desde Cero (2007).

[16] Herrera played Sebastián, a man who pretends to be a professor and steals expensive art work in order to protect his jailed father.

[17] On August 6, 2009, he also guest-starred in an episode of Mujeres Asesinas, "Soledad, Cautiva", alongside his Rebelde co-star Angelique Boyer.

He worked on a television series called El Equipo produced by Pedro Torres where he played a federal policeman named Fermín Pérez.

Alfonso is currently filming a television series called El Diez where he will play a soccer player named 'Chava Espinoza'.

[5] He also was in the Netflix original series Sense8 (2015–18), where he starred as Hernando Fuentes the boyfriend of Lito Rodriguez, played by Miguel Ángel Silvestre.

Between 2016 and 2017, Herrera participated in two episodes of the Mexican series Drunk History, played Che Guevara and again reprised the role of Aquiles Serdán.

[24] Also in 2020, Herrera starred in David Pablos's movie Dance of the 41, playing Ignacio de la Torre y Mier, the gay son-in-law of the President of Mexico.

[25] In 2002, Herrera started dating actress and singer Dulce María; they met during the filming of the soap opera Clase 406, and the relationship ended in 2005.