[6] Jane Adams, Erich Anderson, Omar Avila, Jurnee Smollett-Bell, Geoffrey Blake, Tanner Blaze, Ben Bledsoe, Marc Blucas, Mika Boorem, Kacie Borrowman, David Bowe, Paula Cale, Helen Carey, Greg Cipes, Monique Gabriela Curnen, Dabier, Meredith Eaton, Mary Elizabeth Ellis, Shonda Farr, Arabella Field, Colleen Flynn, Lyndsy Fonseca, Thomas Mikal Ford, Patrick Fugit, Carla Gallo, Christopher Gartin, Jason Winston George, Skyler Gisondo, Meta Golding, Meagan Good, Eve Gordon, Joel Grey, Tracy Howe, Carter Jenkins, Dustin Joiner, Heather Kafka, Krista Kalmus, Tory Kittles, Clare Kramer, Deborah Lacey, Nick Lane, John Larroquette, Brian Leckner, Sheryl Lee, Geoffrey Lewis, Braeden Lemasters, Tess Lina, Jodi Long, Donald Sage Mackey, Bailee Madison, Wendy Makkena, Stephan Markle, Dave Matthews, Shyann McClure, Michael Medico, Joel David Moore, Zeb Newman, Jenny O'Hara, Slade Pearce, Piper Perabo, Adina Porter, Kathleen Quinlan, Annie Quinn, Anne Ramsay, Mercedes Renard, Jake Richardson, Tyson Ritter, Jenny Robertson, Alan Rosenberg, Vyto Ruginis, Jessy Schram, Dustin Seavey, Alyssa Shafer, Kurtwood Smith, Tony Spiridakis, Josh Stamberg, Cassi Thomson, Cooper Thornton, Beverly Todd, Mandy June Turpin, Raviv Ullman, Pruitt Taylor Vince, Jascha Washington, Damien Dante Wayans, Katheryn Winnick and Jamison Yang.
John Larroquette and David Morse submitted the episode "Son of Coma Guy" for consideration in the category of Outstanding Guest Actor in a Drama Series.
House has recovered from his gunshot wounds and is back at work, taking on two cases simultaneously: Richard (Edward Edwards),[12] paralyzed after brain cancer surgery eight years ago, who drove himself on his motorized wheelchair headfirst into a swimming pool, and Caren (Clare Kramer),[13] a young woman paralyzed from the neck down after a yoga session.
Amidst this, Cuddy and Wilson struggle with the fallout from the decision to not to tell House the truth about his last case, thinking he will learn some humility, and Cameron is outraged at their actions when she finds out about the patient.
House takes the case of a young woman (Jurnee Smollett)[20] who is rushed to the hospital with problems breathing and severe stomach pain, after she and her husband (Raviv Ullman)[21] are robbed.
House decides to awaken a patient in a vegetative state (John Larroquette)[25] so he can question the man regarding the family history of his son (Zeb Newman),[26] who may have a genetic condition, and the father is the only living relative.
Meanwhile, Wilson confronts House about the stolen prescription as Tritter approaches Cameron, Chase, and Foreman in an attempt to divide the team and reveal their loyalties.
After a brief review of his file, House thinks he has got the diagnosis, seals it in an envelope and turns the process into a game, challenging Cameron, Foreman and Chase to figure it out on their own.
Meanwhile, House's reduced access to Vicodin is beginning to take its toll and he asks Cuddy for more, but instead of writing a prescription, she strictly rations his pills.
House is forced to respond in court to the criminal charges against him regarding illegal possession of narcotics, and the judge sets a date for a preliminary hearing.
Cuddy insists that House apologize to Tritter; meanwhile, the most recent case at the hospital is a firefighter (Tory Kittles)[34] suffering from disorientation and fluctuating body temperatures.
Celebrity photographer Emma Sloan (Anne Ramsay),[44] who is pregnant, is brought to the hospital after suffering a stroke in the middle of a photo shoot.
Meanwhile, the secret relationship between Cameron and Chase is exposed to Foreman and Cuddy, and House makes extravagant plans to take a much-needed vacation.
House and Cuddy face a widespread outbreak on their plane back from a symposium in Singapore, while Wilson and the rest of the team treat a 58-year old woman (Jenny O'Hara)[46] with constant seizures who is hiding secrets about her lifestyle.
A 14-year-old leukemia patient's (Jascha Washington)[52] only hope of survival is a bone marrow transplant from his younger brother (Dabier),[53] but when he gets sick, the team must race against time to save both siblings.
Speculation over Foreman's resignation continues, while a young girl named Addie (Lyndsy Fonseca)[55] is admitted after bleeding from the mouth during martial arts practice and House and Wilson are secretly concerned about each other.
House meets his match in the form of Nate (Nick Lane),[57] an obnoxious 16-year-old chess prodigy with intense head pain and behavioral issues, who manages to annoy and offend every member of the team during his course of treatment.