[6] Upon his return to Sudan, Bedri was appointed as the first Sudanese doctor to hold the position of assistant deputy director of medical services under Eric Pridie.

[6] Bedri was appointed to the Advisory Council for Northern Sudan and the Sudanisation Committee,[7] and although his civil servant status restricted him from overt political activities, he firmly believed in Sudanese independence.

[6][9][10] Bedri served as Minister of Health in Sudan from 1948 to 1952,[11] during which time he played a significant role in the development and expansion of the country's healthcare services.

[6] During his tenure as Minister of Health before Sudan's independence, Ali Bedri launched a comprehensive ten-year plan aimed at establishing an effective healthcare system in the country.

[6] Bedri was also a leading member of the Society for the Abolition of Female Circumcision,[13][14] Director of the Family Planning Association,[15] and founded the first girls' school in the Sudan.