It was developed by Pfizer in the early 1980s and currently marketed in some countries under the brand name Aclame.

Its half-life under hot or acidic conditions is about twice as long as aspartame's, although some other artificial sweeteners, including saccharin and acesulfame potassium, are more stable yet.

Unlike aspartame, alitame does not contain phenylalanine, and can therefore be used by people with phenylketonuria.

Danisco has withdrawn its petition for using alitame as a sweetening agent or flavoring in food in US.

[3] Sweeny also addresses a compound with a sweetness of 1200 x sucrose in his review,[4] in U.S. patent 4,411,925 based on an NH-CH(cyclopropyl)tert-butyl (Ex 6).