Like most sugar alcohols (including the chemically similar maltitol), isomalt carries a risk of intestinal distress when consumed in large quantities (above about 20–30 g (1 oz) per day).
[1] As with dietary fibers, regular consumption of isomalt can lead to desensitization, decreasing the risk of intestinal upset.
It is also permitted for use in Australia, New Zealand, Canada, Mexico, Iran, the European Union, and other countries.
Isomalt has a minimal cooling effect (positive heat of solution[4]), lower than many other sugar alcohols, in particular, xylitol and erythritol.
[7] In 2023 it was reported that isomalt, when mixed with cellulose or sawdust, can be used as a moldable, recyclable and biodegradable material that's stronger than PVC and PET.