Alkene carboamination

This method represents a powerful strategy to build molecular complexity with up to two stereocenters in a single operation.

[5][6] While intermolecular carboamination is extremely hard, people have developed a strategy to combine the nitrogen and carbon part, which is known as the third class.

It is believed that the pH of the reaction will affect the existing form of the amine nucleophile, which will determine whether the nitrogen coordinates with palladium center or not during the aminopalladation step.

For the C–H activation step in Pd(II)/Pd(IV) chemistry, since there is no directing effect on the aromatic ring, large excess of arenes are required.

[12] In the meantime, Engle and coworkers published a palladium-catalyzed three component carboamination reaction using directing group strategy.