[1] The AIIMS was officially announced on 28 February 2015, in the budget speech for 2015–16, where the Minister of Finance Arun Jaitley announced five more AIIMS, in Jammu & Kashmir, Himachal Pradesh, Punjab, Assam and Tamil Nadu and an "AIIMS-like" institute in Bihar.

Besides Thoppur, Sengipatti (Thanjavur), Pudukottai town, Chengalpattu (Kanchipuram) and Perundurai (Erode) were considered.

[3] In 2018, the union cabinet gave an official approval for the location, on a 222-acre lot in the Thoppur, near Madurai.

Prime Minister Narendra Modi had laid the foundation stone of AIIMS Madurai in January 2019.

[7] The Japan International Cooperation Agency (JICA) informed Minister for Health and Family Welfare of Tamil Nadu Ma.