In 1991, the All Nations Church purchased the land where the centre is located, on Eastern Avenue (part of the main A48 road), opposite the University Hospital of Wales.

[3] The All Nations Centre is a regular host to Welsh organisations including NHS Wales, Public Health Wales, the Welsh Government and Cwm Taf Health Board, as well as for regular Cardiff Council procurement events.

[5] In recent years the centre has been visited by Prince Charles, and has hosted the BBC flagship political debate programme, Question Time.

[6] It is frequently chosen by the Welsh Conservatives as the venue for its hustings and conferences, having previously hosted Prime Ministers David Cameron[7] and Boris Johnson.

[8] The Welsh hustings for the 2019 Conservative Party leadership election were held at the centre.