α,N,O-TMS, or α,N-dimethyl-5-methoxytryptamine, is a lesser-known psychedelic drug.

Its abbreviated nomenclature is derived from its structure, as it is α,N,O-trimethyl serotonin.

α,N,O-TMS was first synthesized by Alexander Shulgin.

In his book TiHKAL (Tryptamines I Have Known and Loved), Shulgin lists the dosage as 10-20 mg when taken orally, and the duration as 6–8 hours.

This psychoactive drug-related article is a stub.