Amazon appears in Lloyd's Register in 1781 with W. Gray, master, Robinson & Co., owners, and trade London–Jamaica.

[4] Then on 16 August 1782, Lloyd's List reported that the transport Amazon, Gray, master, had been taken while carrying clothing to Quebec.

[7][8] In 1793 Portland's officers and crew received prize money for the recapture of Amazon and her cargo.

Amazon reappeared in Lloyd's Register in 1790 with Waring, master, Chapman, owner, and trade London−Smyrna.

On 19 April 1791 Lloyd's List reported that Amazon, Waring, master, had returned from Smyrna.

[13] Lloyd's List for 1799 showed Amazon's master changing from Waring to M'Dowell, and her ownership from Chapman to Cullen.

First voyage transporting enslaved people (1799–1800): Captain William Grahame acquired a letter of marque on 25 February 1799.

[3] Graham sailed from Liverpool on 10 March 1799, bound for the Bight of Biafra and the Gulf of Guinea Islands.

[15] Amazon left the Jamaica fleet on 10 June,[17] and arrived back at Liverpool on 16 July 1800.

[15] Second voyage transporting enslaved people (1800–1802): Captain James Cosnahan acquired a letter of marque on 6 December 1800.

[18] Third voyage transporting enslaved people (1802–1803): Captain John Hunter sailed from Liverpool on 22 October 1802 for Africa.