Amazonía region in southern Colombia comprises the departments of Amazonas, Caquetá, Guainía, Guaviare, Putumayo and Vaupés, and covers an area of 483,000 km2, 35% of Colombia's total territory.

The region is bounded by the East Andes along the western edge and extends to the Venezuelan and Brazilian borders in the east.

The northern limit begins with the Guaviare and Vichada Rivers and extends south to the Putumayo and Amazon Rivers.

The Amazon region is divided up into distinct subregions: Other important rivers include the Vaupés, Apaporis and Yarí.

Within the Colombian Amazon region, there are five moist forest ecoregions: Category