When he sailed across the Atlantic Ocean from Le Havre, France in March 1889, his destination was written on a label tied through a buttonhole on his coat.
After staying with his uncle for a short time, he later returned to Wilkes-Barre, where he attended classes in the evening to learn English, and worked in the Musante fruit store.
Obici operated an eating establishment that served oyster stew and roasted peanuts in a building in downtown Wilkes-Barre.
Some time after Peruzzi's first wife died in 1910 (leaving two children), he married Obici's sister, "Lizzie".
In 1924, Amedeo and Louise Obici moved to Virginia from Scranton and purchased the 253 acre (1 km2) Bay Point Farm located on a bluff overlooking the Nansemond River.
He had a prized herd of Guernsey cows, and distributed Bay Point Dairy Farm milk in Suffolk.
Although area has been reduced through sale, Bay Point Farm still includes the Obicis' home overlooking the Nansemond River and some of the outbuildings, and currently belongs to the City of Suffolk.
Through his estate, Obici also planned and paid for another hospital in his original hometown of Oderzo in Italy.
In 2002, a newer facility replaced the 1951-era Louise Obici Memorial Hospital at a larger site on Godwin Boulevard State Route 10.
Obici Hospital is now affiliated with Sentara Healthcare which operates many health care facilities in southeastern Virginia.
The old hospital site has been redeveloped and turned into a mixed use development with condominiums and retail shops, with the street and property still bearing Louise's name.