The American Federation of Labor Building is a seven-story brick and limestone building located along Massachusetts Avenue in Washington, D.C.[3] Completed in 1916, it served as the headquarters of the American Federation of Labor until 1955, when it merged with the Congress of Industrial Organizations to form the AFL–CIO.

It remained a trade union headquarters until 2005, when it was sold to the developers of the Washington Marriott Marquis hotel.

[3] The building was completed in 1916 to a design by Miburn, Heister & Company for the American Federation of Labor, which was then at a high point in its power and influence.

Samuel Gompers, the organization's leader, characterized it as a monument to the power of labor, and its dedication include a speech by President Woodrow Wilson.

The AFL continued to occupy the building until 1955, when its merger with the CIO prompted a need for additional office space.