Amine fluorides were developed in the 1950s by GABA in collaboration with the Institute of Dentistry of the University of Zurich (Switzerland).
For the first time, in 1954, Wainwright showed in his study the high permeability of tooth enamel to organic molecules like urea.
[2] In the same year, Irwin, Leaver and Walsh published the results of their experiments in vitro, which demonstrated that monoamine-aliphatic compounds offered protection to the enamel against acid decalcification.
The commercial products, which contain amine fluoride or compounds of this with tin-fluoride in their formula, are present under different forms: - gels, - fluids, - dentifrice, - mouth rinse.
Amine fluoride covers the tooth surfaces with a homogeneous molecular layer.