Aminorex, sold under the brand names Menocil and Apiquel among others, is a weight loss (anorectic) stimulant drug.

Aminorex has been shown to have locomotor-stimulant effects, lying midway between dextroamphetamine and methamphetamine.

[10] This seems to call into question the role of direct agonism of the serotonin 5-HT2B receptor in the toxicity of aminorex.

[10] Along similar lines, chlorphentermine, a related drug that has also been associated with such adverse effects, shows negligible direct serotonin 5-HT2B receptor agonistic activity.

It was discovered in 1962 by Edward John Hurlburt,[33] and was quickly found in 1963 to have an anorectic effect in rats.

It was introduced as a prescription appetite suppressant in Germany, Switzerland and Austria in 1965, but was withdrawn in 1972 after it was found to cause pulmonary hypertension in approximately 0.2% of patients, and was linked to a number of deaths.