Her entertainment career began in the music industry, following her performance at the 1993 Asia bagus talent show in Japan.

Mastura also performed a duet with American pop singer Tommy Page, titled "The Best Part".

She gained another hit the following year with Aziz M. Osman's Puteri Impian, a highly acclaimed romantic comedy for which she portrays Nora Mat Jidin, a factory girl who likes to dream and then later to join the reality TV to pursue her dream to be a princess.

[1] She is now actively appears in local television dramas playing both comedy and dramatic roles.

Her mother, Che Pora Din has portrayed as Nora's aunt in Puteri Impian 2 while her father is a retired soldier.

Amy Mastura began her early career as a stewardess with Malaysia Airlines (MAS) from 1989 to 1994.

Her success in acting career has opened the public eye when she worked under the guidance from film director Aziz M. Osman.

At the end of 2000, Mastura began her theatrical debut, entitled Siti Di Alam Fantasi at the Istana Budaya.

Her fifth album, Akan Datang was released a year later, Mastura remains popular as a singer even after becoming a wife and mother.

She also appeared in Cinta 3 Musim jointly produced by her own company, Amy Mastura Entertainment and Aziz M. Osman's Ace Motion Pictures where the drama VCD was released via three stages in 2003.

Her seventh album, Happy was released in 2009 but failed to highlight her as a singer as she is more prominent in acting career.

[6][7] In 2016, Amy Mastura released her new single, "Kalimah", it was her last recording before retired from her singing career after exactly 24 years.

On 7 September, Amy alongside 15 others celebrities will participate in Super Spontan Superstar 2017 which is a reality comedy shows on Astro Warna.

She married her longtime friend who is also an oil rig engineer, Alvin Tham Suffian on 1 July 2000 and they have two daughters, Adriana and Adalia.