Her mother, Nena de la Reguera, was a Miss Veracruz who became a journalist and television personality.

Reguera's acting career began with her role in the telenovela Azul (1996) followed by Pueblo chico, infierno grande (1997), with Verónica Castro, for which she received the Heraldo award for best female acting, and Desencuentro which was her third telenovela under the direction of Ernesto Alonso.

She was immediately offered a role in Tentaciones and Todo por amor, for which she received the Palmas de or award.

[5] Other television credits include Eastbound & Down,[6] Twin Peaks,[7] Power,[8] From Dusk Till Dawn[9] and The Blacklist.

Reguera participated in El Cartero, directed by Raúl Quintanilla, for which she received two awards from the Mexican Association of Theatre Journalists.

Later she appeared in Ladies Night alongside Ana Claudia Talancón, for which she received an MTV Movie Award for 'Favorite Actress'.

In 2017, Reguera served as chair of the ONE Children's Foundation, a 501(c)(3) non-profit organization founded by Claudia Pinto in the city of Los Angeles, which gave birth to Los Angeles en Mexico, a movement created by Reguera, Karla Souza, Kate del Castillo and Olga Segura, after the Puebla earthquake that hit Mexico on September 19, 2017.