[2] Each installment revolves around giant man-eating anacondas and the efforts of various groups of people to capture or destroy the creatures.

The fictional plant known as the Blood Orchid and the company Wexel Hall Pharmaceuticals as well as the fictitious Murdoch family are repeatedly referenced in the films.

A group of researchers embarks on an expedition to the jungles of Borneo in search of the rare Blood Orchid, believed to have medicinal properties.

The film follows a team of scientists working in a remote facility for Wexel Hall where they are experimenting with genetic engineering and the Blood Orchid.

As the snakes escape and wreak havoc, a group of mercenaries and the scientists must work together to stop it before it reaches a populated area.

In January 2020, it was announced that Columbia Pictures was developing a reboot of the 1997 cult film Anaconda, with Evan Daugherty attached to write the screenplay.

[20][21] Snakes on a Babe is an online interactive game produced in 2008 to promote the film Anaconda 3: Offspring from the same year.