For tens of thousands of years it was used as a food and tool source sustainably by the Wurundjeri people, Aboriginal Australians of the Kulin nation, who spoke variations of the Woiwurrung language group.

The creek is relatively uninhibited by weirs, dams or reservoirs and it floods often after heavy rain.

It provides habitat for significant species, which include: platypus, rakali, koalas, powerful owls, rufous night herons, white-winged choughs and yellow-tailed black cockatoos.

In June 1851 gold was first discovered in Victoria on the banks of Andersons Creek at Fourth Hill in the present day Warrandyte State Park[1] by a small group led by Louis John Michel;[2] the township of Warrandyte was initially named after the creek.

Gold can still be found in the creek, and panning is permitted in a small section with a Miners Right.