It is located 2 miles south of Interstate 8, and about 2000 feet west of the Colorado River, in Imperial County opposite the Los Algodones border crossing in Baja California, Mexico.

In spite of its remote desert location, it supports significant tourist traffic volume.

The Andrade-Los Algodones border crossing is also Mexico's northernmost port of entry.

The port ranked 11th for pedestrian crossings in 2010, with more than one million people processed by U.S. Customs and Border Protection.

In the 1990s, medical tourism grew significantly in Los Algodones, with numerous dentists and pharmacies establishing offices primarily for US customers, which contributes to the continued heavy pedestrian crossing numbers[2]