He collaborated with his father and Luca di Tommè on an altarpiece (now lost) for the altar of the shoemaker's guild in the cathedral of Siena in 1389.
His patrons were drawn from the same circles as his father, mendicant religious houses such as the Franciscans of Montalcino and the Dominicans of Siena.
Andrea di Bartolo's creativity is a continuation of the work of his father, who in turn drew on the tradition of Siena, begun by Duccio and Simone Martini.
Andrea had a more summary drawing style and a softer modeling technique than his father and paid less attention to naturalistic detail and expressionism.
For instance, his Coronation of the Virgin (Venice, Ca' d'Oro) shows in its iconography and rich ornamental elements the influence of Venetian painting.