[1] His earliest works suggest that he was in close contact with the workshop of Andrea di Cione.

[2] Andrea di Bonaiuto is known for his stained glass window of the Coronation of Mary in the Basilica of Santa Maria Novella, and his fresco decorations in the Spanish chapel (then called Cappellone degli Spagnoli) of the chapter house there.

The central theme of the frescos in the Spanish chapel is the glorification of the Dominican Order.

He died in Pisa while working on a fresco on the Legend of St Raneiro at the Camposanto Monumentale.

[2] Although a follower of traditional models, Andrea di Bonaiuto brought innovation by softening details and contours with soft and blended shadows and emphasizing the two-dimensional aspect of the painted surface through painted and punched decorative effects.