Andreas Stephanopoulos was born in Pyrgos and was the son of Stephanos Stephanopoulos, a politician and member of the historic Stephanopoulos family.
His brother was politician Christos Stefanopoulos.
He studied law and political sciences in Athens and Paris and was educated early as a politician.
He was elected as a representative for Elis in the Greek parliament in 1892 with Charilaos Trikoupis' party and was re-elected every time until 1929.
He was Minister for Naval Affairs in the 1903 cabinet of Georgios Theotokis; and the Minister for Education in the 1905 cabinet of Theotokis.