[2] Its investments span the healthcare, consumer, cryptocurrency, gaming, fintech, education, and enterprise IT (including cloud computing, security, and software as a service) industries.

[7] In addition to Andreessen and Horowitz, the firm's general partners include John O'Farrell, Scott Weiss, Jeff Jordan, Peter Levine, Chris Dixon, Vijay Pande,[8] Martin Casado, Andrew Chen,[9] and Sriram Krishnan.

[18] According to Horowitz, the investment was seen as risky by other experts in the field who believed the company would be crippled by ongoing intellectual property litigation and direct competitive attacks from Google and Apple.

[25][26] In 2013, Andreessen Horowitz invested in Clinkle, Coinbase, Databricks, Lyft, Oculus VR, PagerDuty, Pixlee, Ripple, Soylent, Swiftype, and uBiome.

[41] Also in 2015 Andreessen Horowitz invested in the blogging platform Medium,[42] Samsara,[43] Improbable,[44] Honor, Inc.,[45] OpenBazaar,[46][47] a blockchain startup, and nootropics and biohacking company Nootrobox.

[72][73] In January 2021, the firm led a $100 million Series B for the audio-chat social networking app Clubhouse, reportedly valuing it at $1 billion.

In October 2021, the firm led the round to Raise $150M Series B at $3B Valuation in Vietnamese studio Sky Mavis, the developer of crypto-based online game Axie Infinity.

[78][79] In December 2021, crowdfunding platform Kickstarter received a $100 million investment from the firm's crypto fund with the expectation that it would pivot to blockchain technology.

[80][81] In March 2022, Andreessen Horowitz led the round to raise $450 million at a $4B Valuation in Yuga Labs (known for Bored Apes).

[82] In October 2022, it was reported that the Securities and Exchange Commission was investigating Yuga Labs due to concerns that sales of their digital assets violated investment laws.

[85] In April 2022, it led a $12 million Series A round for Bounce, a marketplace for consumers to access underutilized space in local businesses.

[87] In August 2022, the firm announced it would invest about $350 million in Flow, the latest organization begun by WeWork founder Adam Neumann.

Flow's purported aim is to create a branded product in the housing market with consistent community features, reimagining how real estate works in the US.