While attending summer camp in the Adirondack Mountains, he gained a lifelong passion for leadership and the outdoors.

Levine was a general partner at Mayfield Fund from 2002 through 2005, prior to becoming president and CEO of Xensource in February 2006.

[4] In March 2011, Levine became a partner at the Silicon Valley venture capital firm Andreessen Horowitz, leading the firm's investments in enterprise software including data center technology, enterprise applications and mobile computing.

[5] Levine has led the firm's investments at GitHub[6] (acquired by MSFT in 2018 for $7.5B[7]), Figma[8] (Announced acquisition of $20B by Adobe[9]), DigitalOcean (DOCN, IPO 2021),[10] Mixpanel,[11] ShieldAI,[12] Apollo GraphQL,[13] PlanetScale,[14][15] and a number of other software companies.

He became a member of the board of trustees of the National Outdoor Leadership School in 2013 for a term through 2019.