[3] His political career included serving as a speaker pro tem in the Maryland House of Delegates and as state's attorney for Washington County.

[3] As Maryland's Attorney General from 1871 to 1875,[2][4] Syester was involved in the prosecution of notable cases, including that of Mrs. Elizabeth (or Ellen) G. Wharton, accused of poisoning.

[3] Syester's career concluded with his role as an associate judge of the Fourth Judicial Circuit from 1882 until 1889, when health issues led to his retirement.

Andrew Kershner Syester died on March 25, 1891,[1] in Hagerstown and was buried in Rose Hill Cemetery[1] in the same city.

His career reflects the changing legal and political dynamics of Maryland in the 19th century, marked by various positions that illustrate the era's complexities rather than individual accomplishments.