[2] Kasarskis is known for taking a network-based approach to biology and for directing the first medical school class offering students the opportunity to fully sequence and analyze their own genomes.

[2] Throughout his career in industry and academia, Kasarskis' research has focused on the use of genetic and genomic data together with high-performance computing and advanced analytical tools to address biomedical needs and improve clinical treatment.

[4] In 2011, Kasarskis became Vice Chair of the Department of Genetics and Genomic Sciences at the Icahn School of Medicine at Mount Sinai and Co-director, along with Eric Schadt, of the Icahn Institute for Genomics and Multiscale Biology, where Kasarskis's research focuses on improving health outcomes through better data mining, and his research program includes sequencing-based pathogen surveillance; pharmacogenomics; electronic health records; and systems biology of sleep, behavior, and stress.

[7][8] Kasarskis is known for directing the first graduate course that allowed medical and PhD students to fully sequence and analyze their own genomes, along with co-instructors Michael Linderman, George Diaz, Ali Bashir, and Randi Zinberg.

Harm van Bakel and others at the Mount Sinai Health System clearly demonstrated that SARS-CoV2, the virus causing COVID-19, was introduced to the New York Metropolitan Area not from Asia but predominately from Europe, with some contribution from other United States regions.