He played in Major League Baseball (MLB) for the Chicago Cubs (1943–51), Brooklyn Dodgers (1951–52), and Milwaukee Braves (1953–59).

[3] Pafko learned about the interest from team manager Ivy Griffin while working on his father's farm.

"[3] In 1941, Pafko played on the Green Bay Blue Sox team in the Wisconsin State League.

[3] Nicknamed "Handy Andy", Pafko was a popular player well known for good hitting and fielding, and contributed to championship-caliber teams in three different cities.

After Cubs third baseman Stan Hack retired the following year, Pafko replaced him at third base long enough to be almost named an All-Star there.

On August 2, 1950, Pafko hit 3 home runs with 5 RBI in an 8-6 loss to the New York Giants at the Polo Grounds.

[4] Pafko was traded to the Brooklyn Dodgers in June 1951 during the middle of the season; he was the left fielder when Bobby Thomson hit the "Shot Heard 'Round the World".

Pafko and Lennie Merullo (died May 30, 2015) were the last two men alive who played for the Cubs in a World Series, prior to 2016.