He has previously played in MLB for the Los Angeles Dodgers, Chicago Cubs, Atlanta Braves, San Francisco Giants, and Arizona Diamondbacks.

Following the 2021-22 lockout, Pederson signed a one-year contract with his hometown San Francisco Giants, and made his second career All-Star Game.

[4][9][a][11] Pederson's Jewish maternal great-great-great-grandfather and great-great-great-uncle immigrated to the United States in the 1840s, and were charter members of synagogue Temple Emanuel in San Francisco.

[2] Following the season, the Dodgers assigned him to the Mesa Solar Sox in the Arizona Fall League, where he was an AFL Rising Star in 2012.

"[66] That night against the Washington Nationals, with the Dodgers trailing 6–4 with two outs and two runners on base, Pederson pinch-hit for pitcher Yimi García.

[65][67] He started in center field the following day, and picked up his first Major League hit on a single off of Doug Fister in the second inning.

[74][75] On May 1, he hit his first major league grand slam off of Rubby De La Rosa of the Diamondbacks, a 446-foot blow.

[84] In 151 games in 2015, he hit .210/.346/.417 with 26 homers (the second-most by a Dodger rookie in franchise history, behind Mike Piazza's 35 in 1993), 67 runs, 54 RBIs, and 92 walks (fifth in the NL).

[94] On June 28, Pederson left a game against the Milwaukee Brewers after spraining his right AC joint while making a diving catch against the outfield wall; he was placed on the DL three days later, but he returned on July 19.

[87] For the second year in a row, Pederson reached the playoffs as the Dodgers clinched their fourth straight NL West title.

[101] In the third inning of Game 4 of the 2016 NLDS against the Nationals, Pederson had a painful RBI, driving in a run when Joe Ross hit him with a pitch with the bases loaded.

[89] Pederson started the 2017 season strong, hitting a grand slam home run on Opening Day (April 3) against the San Diego Padres.

[105] On May 23, in a 2–1 win over the St. Louis Cardinals, Pederson collided with teammate Yasiel Puig in the outfield, and went on the 7-day concussion disabled list.

[89] Seager returned for the 2017 World Series against the Houston Astros, and Granderson was left off the roster to make room for him, opening up playing time for other Dodger outfielders.

[89] In the World Series, Pederson broke a Dodgers postseason record that had been established in 1953, as he had extra-base hits in five consecutive games, surpassing Billy Cox, Andre Ethier, and A.J.

[85][127][128] On May 14, Pederson hit his 100th career home run against San Diego Padres starting pitcher Chris Paddack.

[127] Pederson participated in the Home Run Derby at the 2019 MLB All-Star Game, and lost in the semi-finals to Vladimir Guerrero Jr. in a battle that went to a swing off tie-breaker.

[31] In the first game of the 2019 NLDS against the Washington Nationals, Pederson smashed the hardest-hit Dodgers home run of the year, with a 114.9 mph exit velocity.

[138] Though still used primarily as a corner outfielder, he began getting a few starts at designated hitter as the NL implemented the position for the first time that season.

[69] On February 5, 2021, Pederson signed a one-year $7 million guaranteed contract with the Chicago Cubs which included a mutual option for the 2022 season.

[149] Due to his usual #31 being retired by the Cubs for both Greg Maddux and Fergie Jenkins, Pederson chose to sport the new number of #24 for his tenure with the team as he began the season starting in left field daily.

On July 17, Pederson recorded his first hit as a Brave, a two-run home run in the fourth inning, against Tampa Bay Rays' rookie Josh Fleming.

[162] Then in Game 2 of the 2021 National League Championship Series, Pederson hit a two-run home run against three-time Cy Young Award winner Max Scherzer, as the Braves came from behind to beat the Dodgers 5–4.

[164][165] Through 2021, he had a .501 career slugging percentage against right-handed pitching, and since his first full season in 2015, he ranked 5th among NL outfielders in home runs (130), and 7th in walks (295).

[166] On March 16, 2022, Pederson signed a one-year, $6 million contract with the San Francisco Giants, returning to the National League West, as well as the Bay Area, where he grew up.

His eight RBIs matched the San Francisco-era Giants record also held by Willie Mays, Orlando Cepeda, and Brandon Crawford.

[85] On November 10, the Giants made him a qualifying offer (a one-year contract at the average salary of Major League Baseball's 125 highest-paid players) of $19.65 million, which he accepted to return to the team for another season.

Pederson's mother provided the papers evidencing his Jewish heritage after obtaining them from the synagogue her father Larry Cahn attended.

[190] He played center field for Team Israel manager Ian Kinsler, and alongside pitcher Dean Kremer and others.

[197] The couple's son was born a month before the Dodgers' 2020 World Series championship victory over the Tampa Bay Rays.