[5] Missoni did not enter the fashion industry until her children were old enough to attend school; she started her career as a nursery teacher.

She started her own label at this time, and after a few seasons there, she succeeded her mother as Missoni's creative director.

[11] In 2014, Missoni was given an honorary doctorate of humane letters by the School of Fashion at the Academy of Art University in San Francisco.

In 2017 she received the Fashion Group International of Dallas (FGI) Lifetime Achievement Award.

[14] She currently lives in Milan with her long-time partner, Bruno Ragazzi, who runs Versace's homewares business.