[6] In adults, it is highly expressed in myometrium with lower levels in adrenal gland and fallopian tube.

This receptor functions to mediate signaling in lung fibrosis and regulate nitric oxide synthase expression in pulmonary endothelium.

The modification effect is likely due to variation in gene regulation rather than a change in protein coding sequence.

Variants at the X-chromosome locus containing AGTR2 gene were identified as significantly associating with lung function in patients with cystic fibrosis.

Furthermore, pharmacological antagonism of AGTR2 signaling improved lung function in CF mice to near wild-type levels.