Anguish

It is a paramount feature of existentialist philosophy, in which anguish is often understood as the experience of an utterly free being in a world with zero absolutes (existential despair).

In the theology of Søren Kierkegaard, it refers to a being with total free will who is in a constant state of spiritual fear in the face of their unlimited freedom.

It has been found that the anguish of a significant change in the way a young student lives (i.e. their new responsibilities, being on their own, multiple deadlines etc.)

The study uses a functional magnetic resonance imaging machine to measure the brain waves of a subject when put into a difficult position.

Hearing a song, symphony, or sonnet filled with anguish, one might begin to reflect upon their own life and experiences that coincide with the notes, thereby bringing repressed memories beyond subconscious to our salient mind.

"Hours of anguish" ( Julio Romero de Torres , 1904).