The plot revolves around a girl called Mikiko "Kuromi" Oguro who grows up watching the fictional anime Luis Monde III.

The director of the studio shows her around and gives her the nickname "Kuromi," a name meant to abbreviate her own.

The audience follows Mikiko's frantic attempts and schemes to convince the studio's artists to work harder and produce their key frames in time to send them for production.

Mikiko "Kuromi" Oguro is still working as Production Desk Manager at Studio Petit, and thanks to the excellent job she did, she is now in charge of 3 anime series.

This leaves Mikiko with a difficult decision on which is the more important, the quality of the product or the deadline.