[5] It has been years since the battle between the human race and the monsters has ended, and a new era of peace has started.

[6] The story focuses on the GIRLS rookie members, Agira, Miclas and Windom in their misadventures.

The anime was first announced on March 25, 2016, with the promotional video aired at the AnimeJapan event at Tokyo Big Sight, originally under the title "Kaiju Girls ~Ultra Monster Anthropomorphic Project~ (Tentative)" (怪獣娘 ～ウルトラ怪獣擬人化計画～ （仮）, Kaijū Musume ~ Urutora Kaijū Gijin-ka Keikaku ~ (Kari)).

[6][9] The winning entry for the group name is Capsule Girls (かぷせるがーるず, Kapuseru Gāruzu) and the anime's opening theme is Jōjō ￪￪ GAO! !

The cast of Kaiju Girls are featured as extra characters and all of them are reprised by their original voice actors.